Over the last 50 years Antin has performed and exhibited her work internationally. She has been the subject of numerous major solo institutional exhibitions, including ICA, Boston, MA (2014); San Diego Art Museum, San Diego, CA (2008); Arnolfini, Bristol, UK and Mead Gallery, Warwick, UK (2001); Los Angeles County Museum of Art, Los Angeles, CA (1999) and. In 1975, her seminal exhibition 100 Boots was debuted at MoMA, New York, NY. Often as a performance artist, she has appeared in venues all around the world, including the Serpentine Gallery, London, UK (2017); The Brooklyn Museum (2012); Documenta 12, Kassel, Germany (2007); the 37th International Art Exhibition at the Venice Biennale, Italy (2005) and The Sydney Opera House, Australia (2002). She has received a Lifetime Achievement Award from the Woman's Caucus of the College Art Association, a Guggenheim Foundation Fellowship in 1997, and a Media Achievement Award from the National Foundation for Jewish Culture in 1998.
Her work is included in many important public collections such as the Tate Modern; Art Institute of Chicago; Whitney Museum; Museum of Modern Art (MoMA); The Jewish Museum; San Francisco Museum of Modern Art; Art Institute of Chicago; Centre Pompidou Paris; Museion, Museum of Contemporary Art of Bolzano; Sammlung Verbund Collection, Vienna, amongst others.